Alternative Medicine

"Exercise may slow Alzheimer's progress", Independent Online, South
Africa, May 9, 2005,
Link:


Exercise could slow down the development of Alzheimer's disease and
increase learning abilities by reducing a plaque-forming protein in the
brain linked to the degenerative disease, according to a new study from
the University of California.

A number of human-based studies have already shown that "lifestyle
interventions" such as physical and mental stimulation can delay the
onset and progression of the devastating disease.

The new study used mice to show that "one simple behavioural
intervention - exercise - could delay or even prevent" Alzheimer-like
pathology by decreasing the levels of beta-amyloid proteins in the
brain, according to the write-up in the US Journal of Neuroscience.

The research done by Paul Adlard and his colleagues at the university
used genetically modified mice programmed to develop Alzheimer-like
protein plaque at about three months of age.

Half the mice had access to running wheels and could exercise at will
while the other half were without wheels. When tested in a water maze,
where they had to find a platform to escape, the mice that exercised
were better and faster at navigating their way than the sedentary mice.

After killing the mice, the scientists examined their brain tissue and
found the active mice had hostinghosting percent fewer plaques and beta-amyloid
fragments in their cerebral cortex and hippocampus areas of their
brain-two brain regions used in memory, thinking and decision making.

The results suggested that the damaging protein deposits can be
"reduced and possibly eliminated through exercise, at least in this
mouse model", said Stephen Snyder, director of an Alzheimer's programme
in the National Inshostinghostinghostingute on Aging, a government-funded organisation.

Another recent study linked positive results among mice that were
housed in groups in environments that were enriched with running
wheels, coloured tunnels, and toys.

Alzheimer's Disease, a form of dementia, is a progressive brain
disorder that gradually destroys a person's memory and reasoning
ability and also triggers extreme changes in personality and behaviour.
- Sapa-dpa

Might be due to the increased production of taurine .. a metal binder
...

Nah ..

Who loves ya.
Tom

In humans it may help people with the apoE4 allele.

Arterioscler Thromb Vasc Biol. 2002 Jan;22(1):133-40. Related
Articles, Links


Physical activity may modulate effects of ApoE genotype on lipid
profile.

Bernstein MS, Costanza MC, James RW, Morris MA, Cambien F, Raoux S,
Morabia A.

Division d'Epidemiologie Clinique Hopitaux Universitaires de Geneve,
Centre Medical Universitaire, Geneva, Switzerland.


Increased levels of physical activity may improve the lipid profile,
but is this effect identical across apolipoprotein E (apoE) genotypes?
A population-based cross-sectional survey conducted from 1999 to 2000
included 1708 randomly selected men and women aged 35 to 74 years. A
validated physical activity questionnaire measured, for each
participant, the total energy expenditure and its percentage used in
high-intensity activities (%high-intensity activity), eg, brisk walking
and sports. The effects of the apoEx%high-intensity activity
interaction on the lipid profile were investigated by using multiple
linear regression models. Among men, increased %high-intensity activity
had greater protective effects in the apoE4 group regarding (1) high
density lipoprotein (HDL) cholesterol (P<0.001), compared with either
the apoE2 (interaction P=0.05) or apoE3 (interaction P<0.03) groups,
and (2) triglycerides (P<0.03), compared with the apoE3 group
(interaction P=0.07). A 10% increase of %high-intensity activity by an
apoE4 man would correspond with a 0.07-mmol/L increase in HDL
cholesterol and a -0.15-mmol/L decrease in triglycerides. Among women,
only the protective effects of physical activity on HDL cholesterol in
the apoE4 group versus the apoE2 group was statistically significant.
Spending a larger fraction of the total energy expenditure in
high-intensity activities may counteract the atherogenic effects of the
epsilon4 allele on the lipid profile.

PMID: 11788473 [PubMed - indexed for MEDLINE]

This is true, but it is important for someone
to REMIND the sufferer to exercise!


Joel



"Roman Bystrianyk" <> wrote in message
news: oups.com...
>
>
> "Exercise may slow Alzheimer's progress", Independent Online, South
> Africa, May 9, 2005,
> Link:
>

B252
>
> Exercise could slow down the development of Alzheimer's disease and
> increase learning abilities by reducing a plaque-forming protein in the
> brain linked to the degenerative disease, according to a new study from
> the University of California.
>
> A number of human-based studies have already shown that "lifestyle
> interventions" such as physical and mental stimulation can delay the
> onset and progression of the devastating disease.
>
> The new study used mice to show that "one simple behavioural
> intervention - exercise - could delay or even prevent" Alzheimer-like
> pathology by decreasing the levels of beta-amyloid proteins in the
> brain, according to the write-up in the US Journal of Neuroscience.
>
> The research done by Paul Adlard and his colleagues at the university
> used genetically modified mice programmed to develop Alzheimer-like
> protein plaque at about three months of age.
>
> Half the mice had access to running wheels and could exercise at will
> while the other half were without wheels. When tested in a water maze,
> where they had to find a platform to escape, the mice that exercised
> were better and faster at navigating their way than the sedentary mice.
>
> After killing the mice, the scientists examined their brain tissue and
> found the active mice had hostinghosting percent fewer plaques and beta-amyloid
> fragments in their cerebral cortex and hippocampus areas of their
> brain-two brain regions used in memory, thinking and decision making.
>
> The results suggested that the damaging protein deposits can be
> "reduced and possibly eliminated through exercise, at least in this
> mouse model", said Stephen Snyder, director of an Alzheimer's programme
> in the National Inshostinghostinghostingute on Aging, a government-funded organisation.
>
> Another recent study linked positive results among mice that were
> housed in groups in environments that were enriched with running
> wheels, coloured tunnels, and toys.
>
> Alzheimer's Disease, a form of dementia, is a progressive brain
> disorder that gradually destroys a person's memory and reasoning
> ability and also triggers extreme changes in personality and behaviour.
> - Sapa-dpa
>